![]() Sedating psychotropic drugs with differing mechanisms of action (e.g., antipsychotics, antidepressants, non-benzodiazepine sedative-hypnotics, etc.) may be increasingly prescribed in place of benzodiazepines. Food and Drug Administration added boxed label warnings describing this risk for all opioids and benzodiazepines. ![]() Opioids and benzodiazepines were frequently co-prescribed to patients with pain and psychiatric or neurological disorders however, co-prescription of these drugs increased the risk for severe respiratory depression and death. The regression analysis (slope and correlation coefficient) of the results from instruments run with and without QC samples gave results close to 1, indicating that there is no need to run additional quality control (QC).Ĭonclusion: The POC testing analyzer i-STAT is a reliable alternative to the traditional blood gas analyzers and provides marginal improvement in turnaround time when compared with the service received from the PICU/NICU laboratory. A further study was made to assess whether routine quality control (QC) samples are necessary when using the i-STAT system. There was no significant difference in the results when operated by PICU/NICU nurses or laboratory personnel. Patients' results from the i-STAT correlated well with the Ciba Corning 288 blood gas analyzer ( r = 0.99 for pH, pC0 2, and p0 2 and 0.95 to 0.99 for Na + and K +) with the exception of iCa 2+) ( r = 0.73). Comparison of the i-STAT and the Ciba Corning 288 blood gas analyzer was assessed by split sample measurement. Linearity studies showed good linearity over the five different concentrations tested. Using whole blood studies the precision data gave %CVs that were <3.5 for all the analytes. Except for p0 2, the %CVs were <3.0 for all the analytes (pH, pC0 2, Na + K + and iCa 2+) at all the three concentrations. Results: The system was evaluated for imprecision and linearity using three concentrations of aqueous standards. ![]() The reliability of the i-STAT system when performed by non-laboratory personnel was assessed. Comparison of patients' samples analyzed by the i-STAT system and the Ciba Corning 288 blood gas analyzer were performed. Objective: To evaluate the Point-of-Care (POC) i-STAT system for measuring blood gases (pH, pC0 2, p0 2) and whole blood electrolytes (sodium, Na + potassium, K + and ionized calcium, iCa 2+) in the neonatal and pediatric intensive care units.ĭesign and Methods: The i-STAT system was evaluated for imprecision, necessity of running quality control and accuracy. ![]()
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